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pentobarbital will reduce the extent or result of pimozide by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Slight/Importance Unfamiliar.Monitor Closely (1)pentobarbital will reduce the extent or influence of fentanyl by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Observe Carefully. Coadministration of fentanyl